Getting Healthier Now

A Blog About Digestive Health

Tag: VSL#3

Probiotics: Larger Doses Making a Big Difference

Lactoferrin for SIBO? It seems to be helping most by lowering my inflammation, and I’ll continue taking it daily, but I’ve noticed it also tends to constipate me, which is a bit of a paradox because while the lactoferrin should help kill pathogens and destroy biofilm, a constipated gut is at continued risk for SIBO.

In an effort to counteract this, and get my gut moving, I’ve gone back to the most basic approach of all: probiotics, and lots of them. I figure I can combine this with the lactoferrin, taking the two of them offset as many hours as possible. Lactoferrin with food, and probiotics between meals.

Why not more of my kefir and sauerkraut? I’ve found “enough” is helpful, but too much of either can make me back slide, and I’m not sure why. Especially when my GI tract is sluggish, I think kefir may worsen SIBO by building more biofilm. If anyone has ever tried cleaning a used kefir mason jar, with its thick accumulation of flora after just a few batches, you know what I’m talking about.

If I could deposit the healthy kefir biofilms exclusively in my colon, that would be another matter, but I’ve tried this, more than a few times. Unfortunately, retention enemas with kefir have given me relief only in acute situations, and longer term use doesn’t seem to address all my symptoms.

Probiotics, on the other hand, generally don’t have a reputation for colonizing our guts. Many see this as a drawback, but in the case of SIBO, I am hoping it’s an advantage. Perhaps these temporary upper gut residents will outcompete small intestinal pathogens without setting up shop and compounding the problem.

Recently I came across an interesting evaluation of some common probiotics on PubMed’s site. Note the section on VSL#3, which is a mixture of gram positive bacteria (which do not contain highly inflammatory lipopolysaccharide). Like many probiotics, VSL#3 is a mixture of flora originally harvested from a healthy human donor.

Take note of what it says about VSL#3 helping to heal the gut barrier function. “Leaky gut” is another term for this, and I’ve no doubt that’s one of my biggest problems.

Barrier function was also assessed using mannitol flux assays and after 4 weeks of VSL#3 treatment, barrier function normalized in these mice. Using the T84 human intestinal epithelial cell line it was further shown that VSL#3 and products secreted by these bacteria enhanced intestinal epithelial barrier function in vitro, and pre-exposure of T84 monolayers to VSL#3 provided a dose-dependent decrease in cellular invasion by the pathogenic bacteria Salmonella enterica serovar Dublin. A subsequent study corroborated these findings and further found that VSL#3 upregulated the expression of several mucins which are postulated to play an important cytoprotective role in host defense against pathogens [21].

The expense is a factor, and the primary reason I’ve never stuck with VSL#3 for very long, but could it be a “poor man’s fecal transplant”? With FMT being very costly in a clinic setting, and since I don’t currently have access to a donor for DIY at home, I’m going to give this a shot. The only difference being I’ll take this probiotic orally in addition to retention enemas.

Speaking of upper gut colonization, would the fact that VSL#3 is human-sourced mean its flora will attach permanently to the wall of the small intestine? Likely, the answer is no. This has something to do with how probiotics are manufactured. For some reason, the adherence of probiotic strains on the gut wall is usually not that good, no matter how the flora was originally harvested.

I began with a retention enema using 8 pills of VSL#3 in about 4 ounces of distilled water, using an empty and rinsed Fleet enema bottle. About 5 minutes later I felt my long-gone sense of smell returning. I noticed a basket of essential oils that had been on my dresser for months. Hard to imagine my nose had been so impaired this wasn’t fragrant to me until now, but that’s indeed the case.

About 20 minutes later, I noticed my tinnitus getting quieter, and my whole body relaxing. My mood improved. Joint pain was lessened, also.

Oral administration of VSL#3 was my next step. I took 8 capsules, 2 doses of 4 each, that first day.

I’ve been taking 4 capsules, 3 times per day, between meals, ever since, and drinking 2 pints of distilled water with each dose. I add trace minerals to my water. I only did the retention enema on day 1, and am hoping I can stop it altogether or reduce to once per week.

Now, three days in to the 12 capsules per day oral protocol, here’s a an intriguing list of symptoms where I’m definitely seeing improvements. It’s worth noting a great many of these issues came about after taking fluoroquinolone antibiotics. How much of being “floxed” is due to altered flora?

I should underscore that probiotics are nothing new for me, and VSL#3 is one I’ve used in the past to stop ulcerative colitis flares, but I’ve never taken it in this quantity, nor have I done it with the same frequency, plus I’m also combining the doses with enough water that my stomach acid is probably being diluted, which means more flora survives to reach the colon.

I also think, subjectively, my symptoms were never this bad in previous years, so I never had this far to “bounce back”.

So many symptoms are linked. Overall, I sense a restoration of my vagal nerve function. Huge relief from a constant stuffy nose (neurological, not from typical blockage), my pulse and BP are nice and low, and my sleep patterns and mood are evening out. No more blazing hot colon, lower back and neck, either.

The one thing that hasn’t changed yet, and this is fairly upsetting, is fatigue.

At first I felt strength returning to my legs, and I’d hoped this effect would snowball, but it’s less noticeable now than it was when I first started. Maybe I need to maintain the retention enemas. Another possible explanation for this is lipopolysaccharide being released, as gram positive flora is duking it out with the gram negative ones. If it’s happening in my small intestine, this means more LPS in the bloodstream. Perhaps sorting it all out is just a function of time.

Fatigue is the core of my illness, and Cipro and Levaquin were the triggers for it. I hope as I continue my therapy this will resolve, and it’s clear 3 days of anything gut-related is not enough time to know the longer term potential for healing.

I do hold out lots of hope I can eventually get my energy back, given all the other smaller improvements I’ve seen in the early going. I actually had my housemate take a “before” picture last night, because I’m so shrunken from the SIBO: 6 feet tall and 145 lbs. Underweight is nothing to mess around with, and I know it can significantly impair immunity. I had to do something, and i think i’m finally on the right track.

Have you tried a similar approach, taking large, longer term doses of probiotics? Which type works best for you? And if anyone has figured out a way to “brew” them to reduce the cost, let us know in the comments section below. Thanks.

 

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Food Poisoning? Probiotics to the Rescue.

How many of you heard recently about the amazing Woodrat, ? That’s interesting on its own, but then consider this: if you transplant Woodrat poop to other rodents, even its unrelated brethren can suddenly eat the same toxic stuff.

So it seems clear enough: the healthy bacteria found in Woodrat guts are .

That brings to mind an analogy: all those toxic things I used to be able to gobble up — restaurant food, ancient leftovers, just about any foodtruck fare — before I was prescribed a bunch of nasty antibiotics, including Cipro and Levaquin, a class of drugs the .

Indeed, ever since my gut flora was blasted to smithereens, I’ve had trouble eating anything but the most well-prepared food. Since it’s impossible to always be careful and cook our own meals, a helpful remedy I learned was to start shoveling down probiotics at the first sign of a problem.

, due to a wider range of flora. It’s also effective for ulcerative colitis. Another popular brand is a mix of . A third option: that contains c. butyricum, which generates its own antifungal, anti-inflammatory butyrate, a short chain fatty acid (SCFA) helpful in IBD. Given the lack of butyrate in guts of people with metaboilc issues, c. butyricum .

Back to our restaurant experience gone-awry, or those leftovers that should have been tossed, the theory behind high dose probiotics is they can often overwhelm pathogenic microbes. True enough, I’ve had it work wonders, but in an acute situation of tainted food, it’s not uncommon for me to gulp down 5X the normal dose of VSL#3 and maybe even re-dose a few hours later.

Since it’s not clear how the body will deal with large doses of soil-based bacteria, I am sparing with Prescript Assist and only take VSL #3, or other brands such as , and another multi-strain product, in larger quantities. Keep in mind Renew Life is enteric coated, which means it’s designed to dissolve in the lower GI tract. Therefore, it’s best to open the capsule before dosing, if you need it to work right away.

I’ve also taken (which i just read is a ), , and , when I . These can certainly work well against bad bacteria, but they also degrade the good bugs, so whenever possible I try to avoid herbals and antimicrobials. In the case of . This is one reason .

An additional approach that may help with a toxic gut is . People who have overdosed on medications are often given this in hospitals, and it can work to mop up a lot of organic toxins quickly. Just be aware it will bind with everything, including whatever medicinal supplements you take with it.

So this is the strategy that’s worked for me. What about your own gut? If you find you’re getting GI issues after eating pretty often, and you never used to have that problem, think back to how many courses of antibiotics you may 影梭 have had in your lifetime, or — since we get our gut flora from our mothers — . You may be developing a condition called dysbiosis, which simply means damaged gut flora. Problems often arise from too few bacteria rather than too many.

What are the potential consequences? About 10 years ago I got sick from restaurant food and landed in the ER several hours later with a 104F temp. They gave me (very ironically) IV Levaquin antibiotics to stop the infection. Take that, Woodrat.

Major problems followed, including POTS (a type of neuropathy), food intolerances, SIBO, plus major brain fog, anxiety, tinnitus and insomnia. For those unfamiliar with the term, , which I later learned are actually , not just antibiotics. Anyone who pops Cipro or Levaquin for minor infections, be very careful.

Had I known of this “probiotic rescue” at the time, I could have been overwhelming the bacteria in my upper gut right away, long before I began to develop a fever. Alternatively, I could have been drinking colloidal silver and taking oregano oil, or peppermint oil. Even turmeric and .

NOTE: food poisoning can be serious, so by all means seek medical attention if you feel really sick after a meal. All the measures I’ve mentioned can be tried while you’re preparing for a trip to urgent care, so I hope you’ll be waltzing out of the waiting room early, rather than spending the night. 😉

What about longer term solutions for GI health? Probiotics are expensive, which makes sustained use impractical for many of us, and how effective are they at colonizing the gut? Results vary, but many probiotics are barely “waking up” by the time they leave our bodies. How about asking our easy-going friend with the iron-stomach to do a Yes, FMT, as it’s called, is the ultimate flora fix, but restrictions on its use have created quite a few hurdles.

For most of us, the best answer may be simple, age-old wisdom: eat more cultured foods. They have trillions of healthy bacteria, compared to the billions in expensive probiotics, and that flora is awake and ready to go to work the moment you consume it!

You can learn .

 

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